NTP report on the toxicology study of senna (CAS NO. 8013-11-4) in c57BL/6NTac mice and toxicology and carcinogenesis study of senna in genetically modified c3B6.129F1/Tac-Trp53tm1Brd N12 haploinsufficient mice (Feed studies)
BACKGROUND: Senna is a plant product used in laxatives. We tested senna in a genetically modified mouse strain that shows tumor responses more rapidly than in standard mouse strains. METHODS: We gave groups of male or female heterozygous F1 p53+/− mice feed that contained senna plant material at con...
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| Format: | eBook |
| Language: | English |
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Research Triangle Park, NC
National Toxicology Program
April 2012, 2012
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| Series: | NTP GMM
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| Online Access: | |
| Collection: | National Center for Biotechnology Information - Collection details see MPG.ReNa |
| Summary: | BACKGROUND: Senna is a plant product used in laxatives. We tested senna in a genetically modified mouse strain that shows tumor responses more rapidly than in standard mouse strains. METHODS: We gave groups of male or female heterozygous F1 p53+/− mice feed that contained senna plant material at concentrations of 100, 300, 1,000, 3,000, or 10,000 parts per million for 40 weeks. Tissues from 22 organs were examined for every animal. RESULTS: Epithelial hyperplasia of the large intestine was seen in all the mice receiving the top dose of 10,000 ppm (1%) senna in the feed. The incidences of cancer were not significantly increased in any of the tissues examined. CONCLUSIONS: We conclude that senna caused epithelial hyperplasia of the large intestine in male and female F1 p53+/− mice. Senna exposure for 40 weeks did not cause any cancers in this mouse strain |
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| Physical Description: | 1 PDF file (114 pages) illustrations |