NTP technical report on the toxicology and carcinogenesis studies of antimony trioxide (CASRN 1309-64-4) in wistar han [Crl:WI(Han)] rats and B6C3F1/N mice (Inhalation studies)
CONCLUSIONS: Under the conditions of these 2-year inhalation studies, there was some evidence of carcinogenic activity (see Explanation of Levels of Evidence of Carcinogenic Activity; see a summary of the Peer Review Panel comments and the public discussion on this Technical Report in Appendix L) of...
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| Format: | eBook |
| Language: | English |
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Research Triangle Park, North Carolina
National Toxicology Program, Public Health Service, U.S. Department of Health and Human Services
2017, December 2017
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| Series: | NTP TR
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| Online Access: | |
| Collection: | National Center for Biotechnology Information - Collection details see MPG.ReNa |
| Summary: | CONCLUSIONS: Under the conditions of these 2-year inhalation studies, there was some evidence of carcinogenic activity (see Explanation of Levels of Evidence of Carcinogenic Activity; see a summary of the Peer Review Panel comments and the public discussion on this Technical Report in Appendix L) of antimony trioxide in male Wistar Han rats based on increased combined incidences of alveolar/bronchiolar adenoma or carcinoma in the lung and on increased incidences of benign pheochromocytoma of the adrenal medulla. There was some evidence of carcinogenic activity of antimony trioxide in female Wistar Han rats based on increased incidences of alveolar/bronchiolar adenoma in the lung and on increased combined incidences of benign or malignant pheochromocytoma of the adrenal medulla. The combined occurrence of cystic keratinizing epithelioma and squamous cell carcinoma in the lung may have been related to exposure. TWO-WEEK STUDY IN RATS: Groups of five male and five female core study rats were exposed by whole body inhalation to antimony trioxide aerosol at concentrations of 0, 3.75, 7.5, 15, 30, or 60\smg/m3 for 6 hours plus T90 (12 minutes) per day, 5\sdays per week for 12 exposure days during a 16-day period. Additional groups of five female tissue burden study rats were exposed to the same concentrations for 16 days then held for 28 days without exposure. All rats survived to the end of the study. The mean body weights of exposed groups of males and females were similar to those of the respective chamber control groups. Lung weights of 60\smg/m3 males and 30 and 60 mg/m3 females were significantly greater than those of the chamber controls. Incidences of chronic active inflammation in the lungs were significantly increased in 30 and 60\smg/m3 males and females. There was clear evidence of carcinogenic activity of antimony trioxide in male B6C3F1/N mice based on increased incidences of alveolar/bronchiolar carcinoma of the lung. Increases in the incidences of fibrous histiocytoma in the skin, as well as the combined incidences of fibrous histiocytoma or fibrosarcoma in the skin of male mice were also considered to be related to exposure. There was clear evidence of carcinogenic activity in female B6C3F1/N mice based on increases in the incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar carcinoma of the lung and on increased incidences of malignant lymphoma. The occurrence of squamous cell carcinoma of the skin may have been related to exposure. Exposure to antimony trioxide resulted in increased incidences of nonneoplastic findings of the lung, nose, larynx, trachea, bronchial and mediastinal lymph nodes, and bone marrow of male and female rats and mice; the adrenal medulla, arteries of multiple tissues (mesentery, pancreas, mediastinum, kidney, and lung), kidney, and eye of male and female rats; the thymus and heart of male and female mice; the forestomach of male mice; and the spleen of female mice. Synonyms: A1530; A1582; a1588 lp; antimonious oxide; antimony oxide; antimony (III) oxide; antimony peroxide; antimony sesquioxide; antimony white; AP 50; biantimony trioxide; C.I. pigment white 11; dechlorane a-o; diantimony trioxide; exitelite; flowers of antimony; nyacol a 1530; senarmontite; valentinite; weisspiessglanz Trade names: FireShield(r), Microfine(r), Montana Brand, Thermoguard(r), Timonox, TMS(r), Trutint(r), Ultrafine(r), White Star |
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| Physical Description: | 1 PDF file (various pagings) illustrations |